OxyContin (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, and.
OxyContin contains oxycodone, which is a full mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Oxycodone, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.
In opioid-tolerant patients, the situation is altered by the development of tolerance to opioid-related side effects, and the relationship is not clinically relevant. There is a general relationship between increasing oxycodone plasma concentration and increasing frequency of dose-related opioid adverse experiences such as nausea, vomiting, CNS effects, and respiratory depression.
Accidental ingestion of even one dose of OXYCONTIN, especially by children, can result in a fatal overdose of oxycodone [see Warnings and Precautions (5.2)].
As such, it is preferable to underestimate a patient’s 24-hour oral oxycodone requirements and provide rescue medication (e.g., immediate-release opioid) than to overestimate the 24-hour oral oxycodone requirements and manage an adverse reaction. Although tables of oral and parenteral equivalents are readily available, there is substantial inter-patient variability in the relative potency of different opioid drugs and formulations.
( 6.1 ). Most common adverse reactions (>5%) were constipation, nausea, somnolence, dizziness, vomiting, pruritus, headache, dry mouth, asthenia, and sweating.
For geriatric patients who are debilitated and not opioid tolerant, start dosing patients at 1/3 to 1/2 the recommended starting dosage and titrate the dosage cautiously [see Use in Specific Populations ( 8.5 )]
If the patient is currently taking a central nervous system (CNS) depressant and the decision is made to begin OXYCONTIN, start with 1/3 to 1/2 the recommended starting dosage of OXYCONTIN and monitor patients for signs of respiratory depression, sedation, and hypotension [see Warnings and Precautions ( 5.4 ), Drug Interactions ( 7.1 )]
OXYCONTIN is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate in: Limitations of Use.
Do not abruptly discontinue OXYCONTIN.
Oxycodone Vs. OxyContin Oxycodone is an opiod drug that is the active ingredient in a number of prescription pain relievers including Percocet, Percodan.
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An aspirin will ease a headache or sore muscles, but some pain requires stronger medication. Narcotics, including oxycodone and OxyContin.
Generics are not patented and are generally less expensive than brand-name drugs. Generic drugs are almost identical to brand-name pharmaceuticals in terms of dose, safety, strength and efficacy. In other words, your doctor could prescribe oxycodone or OxyContin and they would serve the same purpose in most cases.
Oxycodone is often mixed with other analgesics, including acetominophen and asprin, to make short-acting pain medications. There are up to 50 different drugs that include oxycodone as an active ingredient, according to Purdue Pharma News and Media.
While sometimes used interchangeably, oxycodone and OxyContin differ in the types of effects they produce. Both drugs exist as Schedule II opiate narcotics.
This chemical reaction changes the way a person experiences pain and can also produce feelings of euphoria and calm in the process. When ingested, both OxyContin and oxycodone bind to these cell sites and stimulate the release of neurotransmitter chemicals.
These cell sites secrete the body's own pain-relieving chemicals, also known as neurotransmitters, on an "as-needed" basis. Opiates work by attaching to certain cell receptor sites located in the brain, along the spinal cord and along the gastrointestinal tract.
Both drugs exist as Schedule II opiate narcotics, meaning they carry a high potential for abuse and addiction.