Side Effects of Oxycontin (Oxycodone HCl) Drug Center

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Oxycodone side effects
Side Effects of Oxycontin (Oxycodone HCl) Drug Center

Gastrointestinal disorders: abdominal pain, diarrhea, dyspepsia, gastritis.

Nervous system disorders: somnolence, hypoesthesia, lethargy, paresthesia.

Renal and urinary disorders: dysuria, hematuria, polyuria, urinary retention.

In addition to the events listed above, the following have also been reported, potentially due to the swelling and hydrogelling property of the tablet: choking, gagging, regurgitation, tablets stuck in the throat and difficulty swallowing the tablet.

The following serious adverse reactions are described elsewhere in the labeling:

A concise overview of the drug for the patient or caregiver from First DataBank.

Ask your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener). Read the entire patient information overview for OxyContin (Oxycodone HCl). This is not a complete list of possible side effects. This is harmless because your body has already absorbed the medicine. l your doctor immediay if any of these unlikely but serious side effects occur: mental/mood changes (such as agitation, confusion, hallucinations), severe stomach/abdominal pain, difficulty urinating. You may report side effects to Health Canada at. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. You may notice an empty tablet shell in your stool. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Many people using this medication do not have serious side effects. In the US - Call your doctor for medical advice about side effects. If you notice other effects not listed above, contact your doctor or pharmacist. A very serious allergic reaction to this drug is rare. In Canada - Call your doctor for medical advice about side effects. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Seek immediate medical attention if any of these rare but serious side effects occur: fainting, seizure, slow/shallow breathing, unusual drowsiness/difficulty waking up. You may report side effects to FDA at 1-800-FDA-1088.

Metabolism and nutrition disorders: anorexia.

Gastrointestinal disorders: abdominal pain, gastroesophageal reflux disease.

Oxycontin (oxycodone hydrochloride) is an opioid drug used for the management of moderate to severe pain, usually for an extended time period; it is not an "as needed for pain (PRN) drug." Oxycontin is available as a generic drug named oxycodone hydrochloride. The most frequent minor side effects of Oxycontin include gastrointestinal (GI) symptoms of constipation, nausea, stomach pain, loss of appetite, and vomiting, and other symptoms including somnolence (sleepiness), dizziness, itching, headache, dry mouth, sweating, and decreases in the ability to feel pain.

General disorders and administration site conditions: withdrawal syndrome (with and without seizures), edema, peripheral edema, thirst, malaise, chest pain, facial edema.

Clinical Trial Experience in Pediatric Patients 11Years and Older.

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Skin and subcutaneous tissue disorders: rash.

What is Patient Information in Detail?

Vascular disorders: postural hypotension.

Injury, poisoning and procedural complications: accidental injury Investigations: ST depression.

What is Prescribing information?

Musculoskeletal and connective tissue disorders: twitching.

The tablets must be swallowed whole because broken or chewed tablets release the drug too rapidly and because Oxycontin is rapidly adsorbed, too concentrated levels will be present in the body which can lead to death. Serious adverse reactions which may occur with Oxycontin are similar to those observed with other opioid analgesics; they include respiratory depression, apnea (stopped breathing), respiratory arrest, circulatory depression, hypotension (low blood pressure), shock, and death. Safety has not been established in children under age 18; caution or avoidance is suggested in pregnant and breastfeeding women as infants can be born with opioid tolerance and depressed respirations. Oxycontin (oxycodone hydrochloride) is available as controlled-release tablets in strengths of 10, 15, 20, 30, 40, 60, 80, and 160 mg tablets (60 mg and above used only for opioid tolerant patients). In addition, low concentrations of Oxycontin have been found in breast milk. Some patients may develop tolerance for Oxycontin and need to be slowly weaned off the drug. This opioid is often the drug of choice for addictive use and can easily lead to dependency.

Here is a collection of user reviews for the medication Oxycontin sorted by most helpful.

Respiratory, thoracic, and mediastinal disorders: oropharyngeal pain.

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

General disorders and administration site conditions: fatigue, pain, chills, asthenia.

You may report side effects to FDA at 1-800-FDA-1088. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur.

Psychiatric disorders: abnormal dreams, anxiety, confusion, dysphoria, euphoria, insomnia, nervousness, thought abnormalities.

Blood and lymphatic system disorders: febrile neutropenia, neutropenia Cardiac disorders: tachycardia.

Table 3 includes a summary of the incidence of treatment emergent adverse events reported in ≥ 5% of patients. The most frequently reported adverse events were vomiting, nausea, headache, pyrexia, and constipation. The median duration of treatment was approximay three weeks. The safety of OXYCONTIN has been evaluated in one clinical trial with 140 patients 11 to 16 years of age.

Last reviewed on RxList 4/6/2015.

Read the OxyContin User Reviews »

Gastrointestinal disorders: dysphagia, eructation, flatulence, gastrointestinal disorder, increased appetite, stomatitis.

The following adverse reactions have been identified during post-approval use of controlled-release oxycodone : abuse, addiction, aggression, amenorrhea, cholestasis, completed suicide, death, dental caries, increased hepatic enzymes, hyperalgesia, hypogonadism, hyponatremia, ileus, intentional overdose, mood altered, muscular hypertonia, overdose, palpitations (in the context of withdrawal), seizures, suicidal attempt, suicidal ideation, syndrome of inappropriate antidiuretic hormone secretion, and urticaria.

OXYCONTIN may increase the risk of serious adverse reactions such as those observed with other opioid analgesics, including respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, or shock.

Table 3: Incidence of Adverse Reactions Reported in ≥ 5.0% Patients 11 to 16 Years System Organ Class Preferred Term 11 to 16 Years (N=140) n (%) Any Adverse Event > = 5% 71 (51) GASTROINTESTINAL DISORDERS 56 (40) Vomiting 30 (21) Nausea 21 (15) Constipation 13 (9) Diarrhea 8 (6) GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS 32 (23) Pyrexia 15 (11) METABOLISM AND NUTRITION DISORDERS 9 (6) Decreased appetite 7 (5) NERVOUS SYSTEM DISORDERS 37 (26) Headache 20 (14) Dizziness 12 (9) SKIN AND SUBCUTANEOUS TISSUE DISORDERS 23 (16) Pruritus 8 (6).

In open-label studies of cancer pain, 187 patients received OXYCONTIN in total daily doses ranging from 20 mg to 640 mg per day. The average total daily dose was approximay 105 mg per day. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety of OXYCONTIN was evaluated in double-blind clinical trials involving 713 patients with moderate to severe pain of various etiologies.

Skin and subcutaneous tissue disorders: hyperhidrosis, rash.

The most common adverse reactions ( > 5%) reported by patients in clinical trials comparing OXYCONTIN with placebo are shown in Table 2 below:

Renal and urinary disorders: dysuria, urinary retention.

Ear and labyrinth disorders: tinnitus.

Skin and subcutaneous tissue disorders: dry skin, exfoliative dermatitis.

Musculoskeletal and connective tissue disorders: pain in extremity, musculoskeletal pain.

Eye disorders: abnormal vision.

Medical Editor: Charles Patrick Davis, MD, PhD.

Common side effects may include:

Report Problems to the Food and Drug Administration.

Metabolic and nutrition disorders: hypochloremia, hyponatraemia.

Find tips and advances in treatment.

General disorders and administration site conditions: chills, fever.

Investigations: oxygen saturation decreased, alanine aminotransferase increased, hemoglobin decreased, plaet count decreased, neutrophil count decreased, red blood cell count decreased, weight decreased.

Respiratory, thoracic and mediastinal disorders: dyspnea, hiccups.

Read the entire FDA prescribing information for OxyContin (Oxycodone HCl).

In clinical trials, the following adverse reactions were reported in patients treated with OXYCONTIN with an incidence between 1% and 5%:

Psychiatric disorders: depression, agitation, depersonalization, emotional lability, hallucination.

You may report side effects to FDA at 1-800-FDA-1088. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur.

Visit the FDA MedWatch website or call 1-800-FDA-1088. You are encouraged to report negative side effects of prescription drugs to the FDA.

Respiratory, thoracic and mediastinal disorders: cough increased, voice alteration.

What is Patient Information Overview?

Read the entire detailed patient monograph for OxyContin (Oxycodone HCl).

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

The following adverse reactions occurred in a clinical trial of OXYCONTIN in patients 11 to 16 years of age with an incidence between ≥ 1.0% and < 5.0%. Events are listed within each System/Organ Class.

Psychiatric disorders: insomnia, anxiety, depression, agitation.

Read the FDA Okays Diclofenac Injection (Dyloject) for Pain article »

Metabolism and nutrition disorders: dehydration.

Anaphylaxis has been reported with ingredients contained in OXYCONTIN. Advise patients how to recognize such a reaction and when to seek medical attention.

"The US Food and Drug Administration (FDA) has approved diclofenac sodium injection ( Dyloject, Hospira Inc), a proprietary nonsteroidal anti-inflammatory drug (NSAID) for the treatment of mild to moderate pain, and for the management of mod".

FDA Okays Diclofenac Injection (Dyloject) for Pain »

TABLE 2: Common Adverse Reactions ( > 5%) Adverse Reaction OXYCONTIN (n=227) (%) Placebo (n=45) (%) Constipation (23) (7) Nausea (23) (11) Somnolence (23) (4) Dizziness (13) (9) Pruritus (13) (2) Vomiting (12) (7) Headache (7) (7) Dry Mouth (6) (2) Asthenia (6) - Sweating (5) (2).

Reproductive system and breast disorders: impotence.

Nervous system disorders: syncope, migraine, abnormal gait, amnesia, hyperkinesia, hypoesthesia, hypotonia, paresthesia, speech disorder, stupor, tremor, vertigo, taste perversion.

Stop using oxycodone and call your doctor at once if you have:

The following adverse reactions occurred in less than 1% of patients involved in clinical trials:

Blood and lymphatic system disorders: lymphadenopathy.

Injury, poisoning, and procedural complications: procedural pain, seroma.

Our Oxycontin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Oxycodone side effects