Oxycodone pharmacology



Oxycodone has a distinctly different pharmacology from morphine

5/17/2016
03:32 | Olivia Holiday
Oxycodone pharmacology
Oxycodone has a distinctly different pharmacology from morphine

Oxycodone is a potent opioid agonist that has been in clinical use for many decades. However, it has only recently been appreciated that oxycodone has a.

Oxycodone is a potent opioid agonist that has been in clinical use for many decades. However, it has only recently been appreciated that oxycodone has a distinctly different pharmacology from that of morphine. Importantly, when administered directly into the lateral ventricle of the rat brain, oxycodone produces dose-dependent, naloxone-reversible pain relief in an acute pain model, indicating that oxycodone itself has intrinsic anti-nociceptive effects (Leow & Smith, 1994). However, oxycodone's intrinsic pain-relieving effects are not attenuated by naloxonazine (-selective opioid antagonist) in a dose that compley blocks the anti-nociceptive effects of an equi-analgesic dose of morphine. Furthermore, the anti-nociceptive effects of intracerebroventricular (icv) oxycodone are compley attenuated by nor-binaltorphimine (-selective opioid antagonist) in a dose that has no significant effect on the levels of anti-nociception evoked by an equi-effective dose of morphine (Ross & Smith, 1997).

Do you want to read the rest of this publication? Wiley.

Oxycodone Ligand page IUPHARBPS Guide to PHARMACOLOGY

4/16/2016
02:42 | Madison Holmes
Oxycodone pharmacology
Oxycodone Ligand page IUPHARBPS Guide to PHARMACOLOGY

The IUPHAR/BPS Guide to Pharmacology. oxycodone ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental.

Molecular properties generated using the CDK Contact us.

Privacy and Cookie Policy Sponsor list.

Ligand id: 7093 Name: oxycodone.

Pharmacology of oxycodone does it explain why oxycodone has

10/22/2016
08:18 | Olivia Holiday
Oxycodone pharmacology
Pharmacology of oxycodone does it explain why oxycodone has

Pharmacology of oxycodone: does it explain why oxycodone has become a As morphine, oxycodone is a m-opioid receptor agonist with a significantly.

Pharmacology of oxycodone does it explain why oxycodone has

9/21/2016
07:08 | Madison Holmes
Oxycodone pharmacology
Pharmacology of oxycodone does it explain why oxycodone has

As morphine, oxycodone is a m-opioid receptor agonist with a significantly different pharmacokinetic profile compared with morphine. It seems.

The pharmacology of oxycodone, Studies In Vitro, In Vivo

8/20/2016
06:02 | Madison Holmes
Oxycodone pharmacology
The pharmacology of oxycodone, Studies In Vitro, In Vivo

THE PHARMACOLOGY OF OXYCODONE,. Studies In Vitro, In Vivo and in Humans. Kim K. Lemberg. Institute of Biomedicine. Pharmacology. University of.