Oxycodone is a potent opioid agonist that has been in clinical use for many decades. However, it has only recently been appreciated that oxycodone has a.
Oxycodone is a potent opioid agonist that has been in clinical use for many decades. However, it has only recently been appreciated that oxycodone has a distinctly different pharmacology from that of morphine. Importantly, when administered directly into the lateral ventricle of the rat brain, oxycodone produces dose-dependent, naloxone-reversible pain relief in an acute pain model, indicating that oxycodone itself has intrinsic anti-nociceptive effects (Leow & Smith, 1994). However, oxycodone's intrinsic pain-relieving effects are not attenuated by naloxonazine (-selective opioid antagonist) in a dose that compley blocks the anti-nociceptive effects of an equi-analgesic dose of morphine. Furthermore, the anti-nociceptive effects of intracerebroventricular (icv) oxycodone are compley attenuated by nor-binaltorphimine (-selective opioid antagonist) in a dose that has no significant effect on the levels of anti-nociception evoked by an equi-effective dose of morphine (Ross & Smith, 1997).
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The IUPHAR/BPS Guide to Pharmacology. oxycodone ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental.
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Ligand id: 7093 Name: oxycodone.
Pharmacology of oxycodone: does it explain why oxycodone has become a As morphine, oxycodone is a m-opioid receptor agonist with a significantly.
As morphine, oxycodone is a m-opioid receptor agonist with a significantly different pharmacokinetic profile compared with morphine. It seems.
THE PHARMACOLOGY OF OXYCODONE,. Studies In Vitro, In Vivo and in Humans. Kim K. Lemberg. Institute of Biomedicine. Pharmacology. University of.