Official Full-Text Publication: Effects of oxycodone on brain responses to emotional images on ResearchGate, the professional network for scientists.
The VMT task consisted of alternating 20-s blocks in whichparticipantssawaflashingcheckerboardwhilepressing a singlebuttonevery secondorsaw a white fixationcross ona black screen while remaining still. Trials are presented for 4 s each, five times per block, two blocks per run; three runs total. 2009; Labuschagne et al. Preprocessing was completed in Statistical Fig. 2010; Phan et al. A high-resolution T1 scan (3D- SPGR; 1.8-ms TE, 9-ms TR, 15° flip, 25.6-cm FOV, 256× 256 matrix, 124 1.2-mm axial slices) was also acquired for anatomical localization.
Rationale: Evidence from animal and human studies suggests that opiate drugs decrease emotional responses to negative stimuli and increase responses to.
AU - De Wit,Harriet.
OXY produced subjective effects but did not alter either behavioral responses to emotional stimuli or activity in our primary areas of interest. OXY did decrease right medial orbitofrontal cortex (MOFC) responses to happy faces. Results: Our emotional tasks reliably activated emotional network areas.
This may indicate that healthy adults do not receive emotional benefits from opiates, or the pharmacological actions of OXY differ from other opiates. Conclusions: Contrary to our expectations, OXY did not affect behavioral or neural responses to emotional stimuli in our primary areas of interest.
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Such emotional effects may motivate misuse of oxycodone (OXY), a widely abused opiate. Yet, we know little about how OXY affects neural.
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First online: 07 May 2014.
We examined effects of OXY on brain activity during presentation of positive and negative visual emotional stimuli. We predicted that OXY would decrease amygdala activity to negative stimuli and increase ventral striatum (VS) activity to positive stimuli. Secondarily, we examined the effects of OXY on other emotional network regions on an exploratory basis.
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Our emotional tasks reliably activated emotional network areas.