Oxycodone hydrochloride tablets, USP is an opioid analgesic. Each tablet for oral administration contains 5 mg, 15 mg or 30 mg of oxycodone hydrochloride.
The analgesic ingredient, oxycodone, is a semi-synthetic narcotic with multiple actions qualitatively similar to those of morphine; the most prominent of these involves the central nervous system and organs composed of smooth muscle. Oxycodone, as the hydrochloride salt, is a pure agonist opioid whose principal therapeutic action is analgesia and has been in clinical use since 1917. Like all pure opioid agonists, there is no ceiling effect to analgesia, such as is seen with partial agonists or non-opioid analgesics.
Each tablet, for oral administration, contains oxycodone hydrochloride and acetaminophen in the following strengths: Oxycodone Hydrochloride, USP 2.5 mg*.
Animal studies to evaluate the carcinogenic potential of oxycodone and acetaminophen have not been performed.
Updated February 25, 2010.
Oxycodone HCl Controlled-Release Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.
As with all opioids, the dose must be individualized (see DOSAGE AND ADMINISTRATION ), because the effective analgesic dose for some patients will be too high to be tolerated by other patients.
Dose proportionality has been established for the 10 mg, 20 mg, 40 mg, and 80 mg tablet strengths for both peak plasma concentrations (C max ) and extent of absorption (AUC) (see Table 1 below). Another study established that the 160 mg tablet is bioequivalent to 2 x 80 mg tablets as well as to 4 x 40 mg for both peak plasma concentrations (C max ) and extent of absorption (AUC) (see Table 2 below).
Professional guide for Oxycodone Hydrochloride. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Hypersensitivity to opiates; upper airway obstruction; acute asthma; diarrhea due to poisoning or toxins.
2009 Wolters Kluwer Health. More... More FDA updates.
Extensively metabolized in the liver to noroxycodone (a major metabolite), oxymorphone, and their glucuronides.
Oxecta - Tablets 5 mg - Tablets 7.5 mg.
Peak plasma oxycodone and noroxycodone concentrations 50% and 20% higher; AUC values are 95% and 65% higher, respectively. Oxymorphone peak plasma concentration and AUC values are lower by 30% and 40%.
2 Answers (question resolved) - Posted in: tylenol, acetaminophen, oxycodone, hydrochloride - Answer: Oxycodone hydrochloride is just simply.
3 answers • 22 Oct 2014.
We comply with the HONcode standard for trustworthy health information - verify here.
This question has also been asked and answered here: Oxycodone vs Hydrocodone - What's the difference between them? 15 Dec 2012.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.