Oxycodone is extensively metabolized and eliminated primarily in the urine as both conjugated and unconjugated metabolites. The apparent elimination half-life (t½) of oxycodone following the administration of OXYCONTIN was 4.5 hours compared to 3.2 hours for immediate-release oxycodone.
The plasma concentrations of oxycodone are only nominally affected by age, being 15% greater in elderly as compared to young subjects (age 21-45).
Oxycodone causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach and duodenum.
There was an increase in mean elimination t½ for oxycodone of 1 hour. Data from a pharmacokinetic study involving 13 patients with mild to severe renal dysfunction (creatinine clearance < 60 mL/min) showed peak plasma oxycodone and noroxycodone concentrations 50% and 20% higher, respectively, and AUC values for oxycodone, noroxycodone, and oxymorphone 60%, 50%, and 40% higher than normal subjects, respectively. This was accompanied by an increase in sedation but not by differences in respiratory rate, pupillary constriction, or several other measures of drug effect.
The precise mechanism of the analgesic action is unknown.
The total plasma clearance was 0.8 L/min for adults. Apparent elimination half-life of oxycodone following the administration of ROXICODONE (oxycodone.
The respiratory depression involves both a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. Oxycodone produces respiratory depression by direct action on brain stem respiratory centers.
Oxycodone hydrochloride is extensively metabolized to noroxycodone, oxymorphone, and their glucuronides.
Common Questions and Answers about Oxycodone and half life aim for a week to be safe, the half-life of oxycodone, meaning half the drug out of your blood.
However, just because it takes oxycodone 4.5 hours, for half of it to become inactive, you must then understand how long it takes the body to rid itself of oxycodone and oxymorphone glucuronides. It is a non-exact science and you really can't go by the half-life alone.