Conversion dose from Oxycontin 40mg 3x a day to morphine sulfate 15 120mg a day of Oxycodone the dose of Morphine Sulfate would be at.
Hi folks... I was just given Morphine sulfate IR, 15 mg, up to 2 every 4 hours. It's not helping that much with the pain, but i don't want to give up. I have a feeling this is a much smaller dose of pain medication if I'm right looking at one conversion chart? It was confusing, but it looked like if I took 120mg a day of Oxycodone the dose of Morphine Sulfate would be at least 250mg a day? ANYONE? 4 Apr 2011.
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RESULTS: The mean (+/-SE) conversion factor used to convert IV PCA morphine to CR oxycodone was 1.2 +/- 0.1 (N=159). The initial CR oxycodone doses.
This study assessed conversion factors utilized by physicians to transfer postoperative patients from intravenous opioids to oral controlled-release (CR) oxycodone and the subsequent analgesic effectiveness.
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This was a multicenter, open-label, usual-use study of 189 hospitalized postoperative patients receiving opioid (usually morphine) intravenous patient-controlled analgesia (IV PCA) for at least 12 to 24 hours post-procedure. Patients who were tolerant of oral medications and without signs of paralytic ileus were converted to oral CR oxycodone, given every 12 hours for up to 7 days.
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The mean (+/-SE) conversion factor used to convert IV PCA morphine to CR oxycodone was 1.2 +/- 0.1 (N=159). The mean +/- SE initial dose of CR oxycodone, for patients converted from IV PCA morphine, was 27 +/- 1 mg; that for all patients was 29 +/- 2 mg. The most common adverse events were constipation, nausea, and pruritus. Pain at the end of the first 12 hours was controlled with these initial doses. The initial CR oxycodone doses, based on individual conversion factors from IV PCA morphine, produced significant reductions in pain intensity (scores <or=4) within 6 hours after the initial dose.
Adverse events were consistent with opioid side effects. Administered at least 12 hours following abdominal, orthopedic, or gynecologic surgery, an initial oral CR oxycodone dose calculated by multiplying the amount of IV morphine used in the previous 24 hours (immediate postoperative period) by a conversion factor of 1.2, on average, provided adequate pain control during the subsequent 12-hour dosing interval and for a maximum of 7 days.
Guide to potencies of opioid analgesics, for dose conversion. Oxycodone, 1.5–2, 4–6-hourly (or 12-hourly if SR tabs), SR tabs, caps, oral soln.
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Approximate relative potencies taken from Twycross R, Wilcock A, Howard P. Palliative Care Formulary (5th ed). Nottingham: Palliativedrugs.com Lyd, 2014. www.palliativedrugs.com.
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Multiply by the potency ratio to convert an opioid dose to the equivalent dose of oral morphine e.g. oral dihydrocodeine 30mg qds = 120mg/day; 120mg x 0.1 = 12mg oral morphine/day.
Divide by the potency ratio to convert an oral morphine dose to the equivalent dose of another opioid e.g. oral morphine 30mg bd = 60mg/day; 60mg/2 = 30mg subcutaneous oxycodone/day.
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Guide to potencies of opioid analgesics, for dose conversion.
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Use column 2 to obtain the equivalent parenteral dose of the new drug. For example, if your Oxycodone (Percocet Oxycontin), 10, 12, 0.8, 3. Propoxyphene.
Note: the ratio from oral to SC / IV is 2:1 on most occasions.
A practical guide from the University of Alberta Multidisciplinary Pain Centre.
Patient-to-patient variability occurs. NB: The table below is a guideline only. Patients should therefore be monitored closely when their opioids are being switched.
Extracted from Alberta Hospice Palliative Care Resource Manual Second edition (2001). A simpler scheme, used by the Regional Palliative Care Program.
Instructions: Use this page to help solve the common problem of figuring out how to convert from one opioid to another, or from more than one drug to a new opioid. It should be noted that good generalisable data in this area is hard to get. The table is a simplified composite of published data, clinical impressions and informal consensus.
I'm only going to compare oral doses, as conversions for insufflated 80mg of Oxycodone is equivalent to 30mg of Hydromorphone (oral).
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