Oxycodone bioavailability



Pharmacokinetics of intranasal Crushed OxyContin and Intravenous

6/21/2016
06:20 | Madison Holmes
Oxycodone bioavailability
Pharmacokinetics of intranasal Crushed OxyContin and Intravenous

OxyContin (Purdue Pharma) is an extended-release oxycodone formulation. Compared with IV oxycodone, the mean IN bioavailability of.

This study evaluated the pharmacokinetic profile of IN OxyContin in comparison to IV oxycodone. The IN drug administration method used in this study is clinically relevant because OxyContin was administered in the manner by which it is commonly abused—by snorting crushed tablets. There are several important study results. First, crushed OxyContin was rapidly absorbed by the IN route and was reliably detected in plasma within 5 minutes of dosing. Second, OxyContin had high intranasal bioavailability: 78% and 75% after 15 mg/70 kg and 30 mg/70 kg, respectively.

Pharmacokinetics and bioavailability of oxycodone and

3/18/2016
03:50 | Matthew Adderiy
Oxycodone bioavailability
Pharmacokinetics and bioavailability of oxycodone and

Pharmacokinetics and bioavailability of oxycodone and acetaminophen following single-dose administration of MNK-795, a dual-layer biphasic.

Jeong HR, An SSA.

International Journal of Nanomedicine 2012, 7:

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Clinical Interventions in Aging 2015, 10:

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Clinical Pharmacology: Advances and Applications 2014, 6:61-62.

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS.

Journal of Pain Research 2015, 8:607-618.

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Pharmacokinetic comparison of intravenous and intranasal

7/22/2016
07:10 | Matthew Adderiy
Oxycodone bioavailability
Pharmacokinetic comparison of intravenous and intranasal

RESULTS: After intravenous administration of oxycodone, the plasma clearance of oxycodone The intranasal bioavailability of oxycodone was 0.46 +/- 0.34.

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Ten healthy volunteers (3 males and 7 females) were given either an intravenous bolus of oxycodone hydrochloride 0.05 mg/kg or nasal sprays of oxycodone hydrochloride 0.1 mg/kg in a cross-over manner. Blood was sampled and subjective effects and side effects were recorded for 10 h.

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For patients with chronic pain, treatment with oral analgesics is considered most convenient and feasible. To investigate the applicability of the nasal route for the administration of oxycodone, we studied the intravenous and intranasal pharmacokinetics of oxycodone in healthy volunteers. Sometimes, however, the oral route cannot be used because of difficulties with swallowing, nausea, vomiting and gastrointestinal obstruction.

After intranasal administration, peak plasma concentration of oxycodone was 13 +/- 6 ng/ml and it was reached in the median time of 25 min. The intranasal bioavailability of oxycodone was 0.46 +/- 0.34. After intravenous administration of oxycodone, the plasma clearance of oxycodone was 0.83 +/- 0.33 l/min (mean +/- SD) and the volume of distribution at steady-state 2.02 +/- 1.47 l/kg and the terminal elimination half-life 157 +/- 47 min. No clinically significant changes in blood pressure or heart rate were observed but all subjects experienced somnolence after both modes of administration.

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The results of this study show that oxycodone is rapidly and rather effectively absorbed from the nasal mucosa but the interindividual differences are large. The intranasal route may in some cases be an attractive alternative to oral or parenteral administration of opioid analgesics. However, because of large interindividual differences, it is prudent to titrate the dose of intranasal oxycodone individually.

Routes of Opioid Analgesic Therapy in Management of Cancer Pain

12/27/2016
12:40 | Olivia Holiday
Oxycodone bioavailability
Routes of Opioid Analgesic Therapy in Management of Cancer Pain

First-pass metabolism decreases the bioavailability of morphine to 30% to 40% to 50%, and oxycodone to 60% to 87%2(p2344) of the total administered dose.

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Oxycodone insufflation bioavailability vs. oral bioavailability

9/24/2016
09:10 | Ethan Adamson
Oxycodone bioavailability
Oxycodone insufflation bioavailability vs. oral bioavailability

I was just wondering what the bioavailability is between oral and insufflationi know that with insufflation you feel the onset faster but it doesn't.

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