Single dose oxycodone and oxycodone plus paracetamol (also known as acetaminophen) for analgesia in adults with acute postoperative pain.
Adverse events and withdrawals information was collected. Pain relief or pain intensity data were extracted and converted into the dichotomous outcome of number of participants with at least 50% pain relief over 4 to 6 hours, from which relative risk and number-needed-to-treat-to-benefit ( NNT ) were calculated. Two review authors independently assessed trial quality and extracted data. Numbers of participants remedicating over specified time periods, and time-to-use of rescue medication, were sought as additional measures of efficacy.
To assess efficacy, duration of action, and associated adverse events of single dose oral oxycodone, with or without paracetamol, in acute postoperative pain in adults.
Efficacy increases when combined with paracetamol.
What's being done about acetaminophen overdoses? prescriptions like Vicodin (hydrocodone/acetaminophen) and Percocet (oxycodone/acetaminophen).
For more information on acetaminophen and liver damage, please see the FDA's Q&A. Top of page.
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Hundreds of over-the-counter (OTC) brands—including Tylenol, Excedrin, Nyquil, TheraFlu, Benadryl, Midol, and Alka-Seltzer—contain acetaminophen, as do common "combination" prescriptions like Vicodin (hydrocodone/acetaminophen) and Percocet (oxycodone/acetaminophen).
Medscape - Indication-specific dosing for Percocet, Tylox (oxycodone/acetaminophen), frequency-based adverse effects, comprehensive interactions.
Maximum dose acetaminophen 4000 mg codeine 360 mg per 24 hours with use of acetaminophen at Oxycodone acetaminophen 5 325 safe maximum dose.
There are actually many that don't contain Acetaminophen. Oxycodone is available by itself in quite a few different dosages. Learn more Oxycodone details here.