Oxycontin has been the most popular and controversial opioid of this century. The time-release pain reliever, originally billed as addiction-proof.
Phillip Smith is editor of the AlterNet Drug Reporter and author of the Drug War Chronicle.
At a time when low-level street dealers get sent to prison for decades when one of their customers overdoses and dies on their product, the Sacklers, whose product has killed thousands and addicted tens or hundreds of thousands more, get to join the list of the country's wealthiest families.
Overdoses, accidental deaths, and addiction followed. Of course, people interested in getting high off opiates quickly figured out that they could just crush the pill to overcome its time-release mechanism, snort the powder, and get as high—or higher—than they could with heroin.
According to the Centers for Disease Control, of the nearly 44,000 drug overdose deaths in the US in 2013, more than half were from prescribed drugs, and of those deaths, 72% were from opiate overdoses.
This would be identical to:
We recommend upgrading to the latest Safari, Google Chrome, or Firefox.
The luaparse executable can be used in your shell by installing luaparse globally using npm: Example usage.
If the following code is executed:
The default options are also exposed through luaparse.defaultOptions where they can be overriden globally.
The lex function is exposed as luaparse.lex() and it will return the next token up until EOF is reached.
J Biol Chem. 2003 Nov 21;278(47): . Epub 2003 Jul 29. Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction.
Generate a file for use with external citation management software.
Gene inactivation studies point to the involvement of OxyC in catalyzing the last oxidative phenol coupling reaction during glycopeptide antibiotic biosynthesis. Presently, the substrate and exact timing of the OxyC reaction are unknown. The substrate might be the bicyclic heptapeptide or a thioester derivative bound to a protein carrier domain. OxyC from the vancomycin producer Amycolatopsis orientalis was produced in Escherichia coli and crystallized, and its structure was determined to 1.9 A resolution. OxyC gave UV-visible spectra characteristic of a P450-like hemoprotein in the low spin ferric state. After reduction to the ferrous state by dithionite the CO-ligated form gave a 450-nm peak in a UV-difference spectrum. The addition of vancomycin aglycone to OxyC produced type I changes to the UV spectrum. OxyC exhibits the typical P450-fold, with the Cys ligand loop containing the signature sequence FGHGX-HXCLG and Cys-356 being the proximal axial thiolate ligand of the heme iron. The observation of a water molecule bound to the heme iron is consistent with the UV-visible spectra of OxyC indicating a low spin heme. A polyethylene glycol molecule occupying the active site might mimic the bicyclic heptapeptide substrate. Analysis of the structure of Oxy-proteins and other P450s indicates regions that might be involved in binding of the redox partner and possibly the protein carrier domain.
National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.
Oxyc Woody II by Human Resources, released 12 April 2012 1. Hey, Predator Drone 2. Stinger Sisters 3. Fucking at the SkyMall 4. Private Booths For Sallow.
Streaming and Download help Redeem code.
Fire Talk Brooklyn, New York Contact Fire Talk.