OxyFast Oral Concentrate Solution, OxyIR Capsules (Purdue Pharma), OXYFAST 20 mg/1 mL solution is a highly concentrated solution.
NDC : Opaque plastic bottle containing 100 capsules.
The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and play a role in the analgesic effects of this drug.
Oxycodone produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves both a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation.
Patients receiving other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics or other CNS depressants (including alcohol) concomitantly with oxycodone hydrochloride may exhibit an additive CNS depression.
Short acting forms are Roxanol and MS-IR. Oral solutions:4 and 20mg/ml. 20 mg. Long acting forms are Oxycodone ER and Oxycontin. Comes as 10,20,40,80.
PCA: 1or 5mg/ml 30ml Codeine 200 mg 120 mg 3-4 hours. Comes as inj:2,4,10mg. 4-5 times as potent as morphine. Tablet:2,4,8,16mg. Suppository:3mg.
It is dosed as bid. Comes as 5 mg and 15 mg tablets, 1mg/ml oral solution. Short acting forms are Oxy-IR and Roxicodone. Comes as 10,20,40,80 mg. Long acting forms are Oxycodone ER and Oxycontin. Use 1/10th of the long acting form as the rescue dose. Slightly more potent than morphine. If more than 5 rescue doses are required then increase the long acting form. Hydrocodone 30 mg NA.
MS Contin is bid dosing. Hydromorphone 8 mg 3 mg 3-4 hours. Extended release:15,30,60,90 and100mg. Tablet:15mg, suppository:10mg, injection:2,4,8,10,15mg/ml, PCA:1 or 5mg/ml 30ml. Oral solutions:4 and 20mg/ml. Kadian and Avinza are once daily dosing. Use 1/10th of the long acting form as the rescue dose and if 5 rescue doses are required per day, then increase the long acting form. Short acting forms are Roxanol and MS-IR.
Drug Oral dose Parenteral dose Duration of relief Comments Morphine 30 mg 10 mg 3-4 hours.
T#2 has codeine 15mg, T3# has 30mg and T#4 has 60mg codeine Fentanyl.
20 mg (acute pain), 2-4 mg (chronic pain) 10 mg 4-6 hours.
The patch (TTS) comes as 25,50,75 and 100mcg/hr. Comes as 50mcg/ml inj. Oxycodone 20 mg. No oral form available. Takes 8-12 hours for peak effect. Patch is changed q72 hours.
Unpredictable and long half-life. When switching to methadone from another opioid start with 10-25% of the equianalgesic dose and titrate slowly q 3-7 days. Drug accumulates with frequent dosing. Comes as 10mg tablet.
No oral prep. Transdermal 15 mcg/hr 0.2 mg 72 hours.
Vicondin 5/500, vicodin ES 7.5/750, Lortab 2.5, 5, 7.5 with APAP 500, Norco 2.5, 5, 7.5, 10 with APAP 325 (lowest Apap dose), (Morphine: hydrocodone = 1:1) Methadone.
IR stands for immediate release i.e. fast-acting and CR stands for controlled release: OxyNorm (oxycodone IR) capsules: 5 mg, 10 mg, 20 mg. Oxycodone CR.
Note: When taken orally, oxycodone is more potent than morphine - 10 mg oral morphine @ 5 mg oral oxycodone.
Note: Only the electronic version is controlled. Send Feedback Topic Code: 4060. Once printed, this is no longer a controlled document.
fast-acting and CR stands for controlled release:. Available in four formulations. IR stands for immediate release i.e.
Oxycodone should be prescribed with caution if GFR < 30 mL/ min.
Open as a PDF file: Opioid Conversion Guide or view below: See:
Kate Grundy (see Who's Who ) Issue Date: March 2016 Next Review: March 2018 Keywords:
Oxycodone is contraindicated if GFR < 15 mL/min.
The main indications for use at present are:
Morphine therefore remains the drug of first choice. Oxycodone is similar to morphine in its action and has a similar side effect profile. This drug is more expensive than morphine and there is no clinical evidence to support its use first line.
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Oxycodone containing medications, indications and usages, combinations with OXYCODONE BY PRO DOC 20MG TABLET Oxy-Ir 20 mg Tablet, 0.74 USD.