Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of postoperative pain: a double-blind, placebo- and active-controlled parallel-group study.
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In this study, a single dose of oxycodone 5 mg/ibuprofen 400 mg was fast-acting, effective, and well tolerated in subjects with moderate to severe pain after dental surgery. Oxycodone 5 mg alone did not provide an efficacy benefit over placebo in this study.
Combination therapy was associated with greater analgesia than ibuprofen alone, oxycodone alone, or placebo (mean TOTPAR6: 13.3, and 4.2, respectively [P < 0.001 vs oxycodone or placebo, P = 0.012 vs ibuprofen]; mean SP1D6: 6.54, and 0.32, respectively [P < 0.001 vs oxycodone or placebo, P = 0.002 vs ibuprofen]). A total of 498 subjects were randomized to treatment (187 to oxycodone 5 mg/ibuprofen 400 mg, 186 to ibuprofen 400 mg, 63 to oxycodone 5 mg, and 62 to placebo). Pharmacokinetic results implied no interaction between oxycodone and ibuprofen. Baseline demographics were generally similar among treatment groups, despite differences in sex (P = 0.041) and race (P = 0.023). Combination therapy was well tolerated.
Primary efficacy variables were the sum of pain intensity difference over 6 hours (SP1D6) and total pain relief through 6 hours (TOTPAR6). In this multicenter, double-blind, double-dummy, parallel-group investigation, subjects with moderate to severe pain within 5 hours after extraction of > or =2 ipsilateral bony impacted third molars were randomized to single doses of oxycodone 5 mg/ibuprofen 400 mg, ibuprofen 400 mg, oxycodone 5 mg, or placebo. The pharmacokinetics of oxycodone and ibuprofen, alone and in combination, were also determined in a subset of patients.
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This study compared the efficacy and safety of a single dose of oxycodone 5 mg/ibuprofen 400 mg versus its individual components and placebo in a third-molar extraction model.
So the body mass size alone probably will mean I need twice as much medication as a "normal" person). All I have is 70 tablets of OXYCODONE. Not the kind.