How does oxycodone work



How Does Oxycodone Work? Oxycodone Addiction Help

11/14/2016
02:21 | Joshua Addington
How does oxycodone work
How Does Oxycodone Work? Oxycodone Addiction Help

Oxycodone affects users by binding to opioid receptor sites which blocks nerve signals and increases levels of dopamine. It can be addictive and should be.

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Oxycodone is an opioid, a synthetic drug chemically similar to opiates like morphine or heroin. Oxycodone is manufactured from thebaine, a constituent of opium, and which can be highly addictive if used inappropriay.

Oxycodone may also cause feelings of pleasure or euphoria, which is why many people abuse it. This is due to the fact that opioids flood the body with dopamine, the body’s feel-good neurotransmitter. Dopamine encourages people to repeat activities that are beneficial, such as eating and procreation.

Grapefruit juice enhances the exposure to oral oxycodone

8/11/2016
01:09 | Hannah Hoggarth
How does oxycodone work
Grapefruit juice enhances the exposure to oral oxycodone

Basic Clin Pharmacol Toxicol. 2010 Oct;107(4):782-8. doi: 10.1111/j.1742-7843.2010.00582.x. Grapefruit juice enhances the exposure to oral oxycodone.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

Grapefruit juice alters the concentrations of many CYP3A substrates. The objective of this study was to examine the effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of oral oxycodone in a randomized cross-over study with two phases at an interval of 4 weeks. Twelve healthy volunteers ingested 200 ml of grapefruit juice or water t.i.d. for 5 days. An oral dose of oxycodone hydrochloride 10 mg was administered on day 4. Oxycodone, noroxycodone, oxymorphone and noroxymorphone concentrations were analysed from the plasma samples for 48 hr and behavioural and analgesic effects were recorded for 12 hr. Grapefruit juice increased the mean area under the oxycodone concentration-time curve (AUC(0-∞) ) by 1.7-fold (p<0.001), the peak plasma concentration by 1.5-fold (p<0.001) and the half-life of oxycodone by 1.2-fold (p<0.001) as compared to the water. The metabolite-to-parent AUC(0-∞) ratios (AUC(m)/AUC(p) ) of noroxycodone and noroxymorphone decreased by 44% (p<0.001) and 45% (p<0.001), respectively. Oxymorphone AUC(0-∞) increased by 1.6-fold (p<0.01) after grapefruit juice, but the AUC(m)/AUC(p) remained unchanged. Pharmacodynamic changes were modest and only self-reported performance significantly impaired after grapefruit juice. Analgesic effects were not influenced. Grapefruit juice inhibited the CYP3A4-mediated first-pass metabolism of oxycodone, decreased the formation of noroxycodone and noroxymorphone and increased that of oxymorphone. We conclude that dietary consumption of grapefruit products may increase the concentrations and effects of oxycodone in clinical use.

How long does oxycodone work? Yahoo Answers

5/8/2016
04:39 | Matthew Adderiy
How does oxycodone work
How long does oxycodone work? Yahoo Answers

What does it do if your not in any pain and can you take it with other drugs? does one pill work?.

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How does oxycodone work in the body

9/12/2016
12:01 | Matthew Adderiy
How does oxycodone work
How does oxycodone work in the body

Oxycodone, an opiate analgesic, creates several different effects in the body. This releases the brain's natural endorphins of pleasure, such as serotonin and dopamine. These endorphins are what causes the feeling of "euphoria" or intense happiness when oxycodone is taken.

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How long does it take oxycodone to kick in?

10/13/2016
01:11 | Olivia Holiday
How does oxycodone work
How long does it take oxycodone to kick in?

I have notice it takes longer for the oxy to start working then the percocet. I am on the 20mg er oxycodone (generic for oxycontin 20 mg cr) on.

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