However, abuse of OxyContin by these routes, as well as by the oral route. Concomitant use of CYP3A4 inhibitors may prolong opioid effects.
– Sept. 2 – 6 in Las Vegas. These studies also show that declines in abuse and diversion have persisted three years since the introduction. Stamford, Conn. 4, 2014 – Purdue Pharma is presenting results from two epidemiological studies evaluating the reformulation of OxyContin, which occurred in 2010, that showed a marked decrease in rates of abuse, addiction and poisoning in the first year after the product was introduced to the marketplace with physicochemcial properties intended to decrease abuse, misuse and diversion by various routes of administration (e.g., snorting and intravenous injection).
The propensity for addiction to OxyContin and the trend of increased prescription drug We review the specific effects of the drug on body systems and the.
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We review the specific effects of the drug on body systems and the recognition of symptomatology, differential diagnosis, and management. In this review of OxyContin, we discuss current trends in its abuse and the clinical presentation of overdose.
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OxyContin overdose presents with a typical opiate toxidrome, including decreased respirations, miosis, hypothermia, bradycardia, hypotension, and altered mental status. Even in the absence of a confirmation, cautious administration of naloxone--the opiate receptor antagonist and antidote for opioid overdoses--may have both diagnostic and therapeutic effects. If OxyContin overdose is suspected, early ventilation and oxygenation should be administered, which is generally sufficient to prevent death. The presence of coingestants can cloud the clinical picture. Many of the clinical findings in acute opioid overdoses are nonspecific, making diagnosis difficult.
Physicians should be aware of potential patients who are seeking OxyContin for recreational use. With increasing rates of prescription drug abuse, OxyContin will continue to present challenges to physicians and health care providers.
Crushing and snorting the delayed-release tablets results in a rapid release of the drug, increased absorption, and high peak serum concentrations. The propensity for addiction to OxyContin and the trend of increased prescription drug abuse have made it imperative for physicians and health care providers to recognize the clinical presentation of overdose and know how to manage associated complications. OxyContin (controlled-release oxycodone hydrochloride) (Purdue Pharma, Stamford, CT) was approved in 1995 by the US Food and Drug Administration (FDA) for moderate-to-severe chronic pain.